Lynn G Feun Selected Research

Argininosuccinate Synthase (Argininosuccinate Synthetase)

2/2020	Collaboration Between RSK-EphA2 and Gas6-Axl RTK Signaling in Arginine Starvation Response That Confers Resistance to EGFR Inhibitors.
12/2017	Degradation of AMPK-α1 sensitizes BRAF inhibitor-resistant melanoma cells to arginine deprivation.
1/2017	Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy.
12/2016	Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1α, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation.
4/2016	BRAF inhibitor resistance enhances vulnerability to arginine deprivation in melanoma.
3/2015	Targeting argininosuccinate synthetase negative melanomas using combination of arginine degrading enzyme and cisplatin.
1/2015	Arginine deprivation in cancer therapy.
12/2014	Combination of arginine deprivation with TRAIL treatment as a targeted-therapy for mesothelioma.
1/2013	Arginine deprivation therapy for malignant melanoma.
8/2010	Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes.

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Lynn G Feun Research Topics

Disease

24	Neoplasms (Cancer) 07/2021 - 10/2005
11	Melanoma (Melanoma, Malignant) 07/2021 - 01/2002
6	Starvation 01/2021 - 08/2010
6	Hepatocellular Carcinoma (Hepatoma) 12/2019 - 01/2003
5	Lung Neoplasms (Lung Cancer) 07/2021 - 01/2009
2	Glioblastoma (Glioblastoma Multiforme) 01/2020 - 11/2010
2	Disease Progression 10/2019 - 12/2015
2	Glioma (Gliomas) 11/2010 - 04/2007
2	Brain Neoplasms (Brain Tumor) 04/2007 - 01/2002
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2021
1	Diplopia (Double Vision) 01/2021
1	Uveal melanoma 01/2020
1	Diarrhea 12/2019
1	Nausea 12/2019
1	Vomiting 12/2019
1	Hepatitis 10/2019
1	Motor Neuron Disease (Primary Lateral Sclerosis) 07/2017
1	Meningioma (Meningiomas) 12/2015
1	Malignant Mesothelioma 12/2014
1	Mesothelioma 12/2014
1	End Stage Liver Disease 05/2010

Drug/Important Bio-Agent (IBA)

15	Arginine (L-Arginine)FDA Link 07/2021 - 10/2005
12	EnzymesIBA 01/2021 - 10/2005
10	Argininosuccinate Synthase (Argininosuccinate Synthetase)IBA 02/2020 - 08/2010
7	ADI PEG20IBA 07/2021 - 10/2005
7	Cisplatin (Platino)FDA LinkGeneric 07/2021 - 01/2009
5	Pharmaceutical PreparationsIBA 07/2021 - 01/2015
5	arginine deiminaseIBA 07/2021 - 10/2005
4	Glutamine (L-Glutamine)FDA Link 01/2021 - 11/2013
4	Amino Acids FDA Link 01/2021 - 10/2005
3	Reactive Oxygen Species (Oxygen Radicals)IBA 07/2017 - 01/2009
3	Proteins (Proteins, Gene)FDA Link 04/2016 - 01/2002
2	KynurenineIBA 07/2021 - 01/2020
2	Tryptophan (L-Tryptophan)FDA Link 07/2021 - 01/2020
2	PlatinumIBA 07/2021 - 01/2015
2	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 11/2013
2	AntioxidantsIBA 01/2017 - 03/2012
2	ArginaseIBA 01/2015 - 08/2010
2	CitrullineIBA 12/2014 - 08/2010
2	Type I DNA Topoisomerases (Topoisomerase I)IBA 11/2010 - 04/2007
1	LigandsIBA 07/2021
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2021
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 07/2021
1	SirtuinsIBA 07/2021
1	Asparaginase (Elspar)FDA Link 01/2021
1	Proline (L-Proline)FDA Link 01/2021
1	AsparagineIBA 01/2021
1	Small Cytoplasmic RNAIBA 01/2020
1	trametinibIBA 01/2020
1	dabrafenibIBA 01/2020
1	Immune Checkpoint InhibitorsIBA 01/2020
1	fisogatinibIBA 12/2019
1	Biomarkers (Surrogate Marker)IBA 10/2019
1	pembrolizumabIBA 10/2019
1	Programmed Cell Death 1 ReceptorIBA 10/2019
1	B7-H1 AntigenIBA 10/2019
1	ChemokinesIBA 10/2019
1	Interleukin-10 (Interleukin 10)IBA 10/2019
1	CytokinesIBA 10/2019
1	Sorafenib (BAY 43-9006)FDA Link 10/2019
1	pasireotideIBA 01/2018
1	Proteasome Endopeptidase Complex (Proteasome)IBA 12/2017
1	UbiquitinIBA 12/2017
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 12/2017
1	Riluzole FDA LinkGeneric 07/2017
1	Glutamic Acid (Glutamate)FDA Link 07/2017
1	Neoplasm Antigens (Tumor Antigens)IBA 06/2017
1	Recombinant ProteinsIBA 01/2017
1	Histones (Histone)IBA 01/2017
1	Bortezomib (Velcade)FDA Link 12/2016
1	carfilzomibIBA 12/2016
1	Mifepristone (RU 486)FDA Link 12/2015
1	Progesterone Receptors (Progesterone Receptor)IBA 12/2015
1	Antineoplastic Agents (Antineoplastics)IBA 01/2015
1	Tumor Biomarkers (Tumor Markers)IBA 12/2014
1	ThioredoxinsIBA 03/2012
1	Topoisomerase I InhibitorsIBA 11/2010
1	elesclomolIBA 01/2009
1	Irinotecan (Camptosar)FDA LinkGeneric 04/2007
1	Teniposide (VM 26)FDA Link 04/2007
1	Etoposide (VP 16)FDA LinkGeneric 04/2007
1	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 10/2005
1	methoxypolyethylene glycol succinimidylsuccinateIBA 10/2005
1	Essential Amino AcidsIBA 10/2005
1	Interferon-alpha (Interferon Alfa)IBA 01/2003
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2003
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2002
1	Filgrastim (Neupogen)FDA Link 01/2002
1	ProcollagenIBA 01/2002
1	Dacarbazine (DIC)FDA LinkGeneric 01/2002

Therapy/Procedure

12	Therapeutics 07/2021 - 03/2012
6	Drug Therapy (Chemotherapy) 07/2021 - 08/2010
2	Immunotherapy 01/2020 - 06/2017
1	Salvage Therapy 07/2021
1	Telescopes 01/2021
1	Liver Transplantation 05/2010
1	Combination Drug Therapy (Combination Chemotherapy) 01/2003